The Use of In Silico Genome-Scale Models for the Rational Design of Minimal Cells

@inproceedings{Lachance2019TheUO,
  title={The Use of In Silico Genome-Scale Models for the Rational Design of Minimal Cells},
  author={Jean-Christophe Lachance and S{\'e}bastien Rodrigue and Bernhard O. Palsson},
  year={2019}
}
Organism-specific genome-scale metabolic models (GEMs) can be reconstructed using genome annotation and biochemical data available in literature. The systematic inclusion of biochemical reactions into a coherent metabolic network combined with the formulation of appropriate constraints reveals the set of metabolic capabilities harbored by an organism, hereby allowing the computation of growth phenotypes from genotype information. GEMs have been used thoroughly to assess growth capabilities… Expand
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