The Use of Granulocyte Colony-Stimulating Factor in Clozapine Rechallenge: A Systematic Review

@article{Lally2017TheUO,
  title={The Use of Granulocyte Colony-Stimulating Factor in Clozapine Rechallenge: A Systematic Review},
  author={J. Lally and Steffi Malik and A. Krivoy and E. Whiskey and D. Taylor and F. Gaughran and R. Flanagan and A. Mijovic and J. MacCabe},
  journal={Journal of Clinical Psychopharmacology},
  year={2017},
  volume={37},
  pages={600–604}
}
  • J. Lally, Steffi Malik, +6 authors J. MacCabe
  • Published 2017
  • Medicine, Psychology
  • Journal of Clinical Psychopharmacology
  • Purpose/Background Clozapine is associated with hematological abnormalities, with neutropenia and agranulocytosis of most concern. Granulocyte colony-stimulating factor (G-CSF) has been used to support clozapine rechallenge after neutropenia with the aim of maintaining the neutrophil count. This study aims to explore the practice, use, safety, and efficacy of G-CSF in this context. Methods/Procedures We conducted a systematic review to identify all studies investigating or describing G-CSF as a… CONTINUE READING
    Clozapine-induced agranulocytosis
    Sudden death in schizophrenia
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