The Use of Corticosteroids to Treat Keloids: A Review

@article{Roques2008TheUO,
  title={The Use of Corticosteroids to Treat Keloids: A Review},
  author={Claude Roques and Luc T{\'e}ot},
  journal={The International Journal of Lower Extremity Wounds},
  year={2008},
  volume={7},
  pages={137 - 145}
}
  • C. Roques, L. Téot
  • Published 1 September 2008
  • Medicine
  • The International Journal of Lower Extremity Wounds
Mechanisms for keloid formation include drastic changes in growth factor actions, collagen turnover, mechanical forces applied over the skin, and genetic and immunologic contributions. The use of corticosteroids to manage keloids increases basic fibroblast growth factor production while decreasing transforming growth factor-β1 production by human dermal fibroblasts, endogenous vascular endothelial growth factor, and insulin-like growth factor-1. The use of corticosteroid injections is, to date… 
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References

SHOWING 1-10 OF 32 REFERENCES
Keloid Pathogenesis and Treatment
TLDR
Combination therapy, using surgical excision followed by intradermal steroid or other adjuvant therapy, currently appears to be the most efficacious and safe current regimen for keloid management.
Ineffective Treatment of Keloids with Interferon Alpha-2b
TLDR
Interferon does not appear to be effective in the clinical management of keloid management, and recurrence in either group did not correlate with location of the keloids or race.
Treatment of keloids and hypertrophic scars.
  • S. Mutalik
  • Medicine
    Indian journal of dermatology, venereology and leprology
  • 2005
TLDR
There are no set guidelines for the treatment of keloids, so treatment has to be individualized depending upon the distribution, size, thickness, and consistency of the lesions and association of inflammation.
Keloids: pathophysiology and management.
TLDR
This review highlights the clinical features, pathophysiology and management of keloids, and concludes that Combination therapy is likely the optimal strategy.
Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloids.
TLDR
These results provide a rationale for the treatment of keloids with topical rapamycin analogs, including tacrolimus, and clinical trials of topical tacolimus are warranted.
Keloids and Hypertrophic Scars: Are They Two Different Sides of the Same Coin?
  • O. Köse, A. Waseem
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2008
TLDR
The aim of this review is to provide updated information regarding similarities and differences between keloids and hypertrophic scars as two different sides of the same coin to enable the dermatologist to better understand fundamental biology of the scarring.
Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation.
TLDR
Modulation of VEGF production may comprise a valuable treatment modality for keloids after topical intra-lesional steroid injections suppress vascular endothelial growth factor (VEGF) expression in keloid tissue and induce its regression in vivo.
Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods
  • B. Atiyeh
  • Medicine
    Aesthetic Plastic Surgery
  • 2006
TLDR
This review explores the various treatment methods for hypertrophic scarring described in the literature including evidence-based therapies, standard practices, and emerging methods, attempting to distinguish those with clearly proven efficiency from anecdotal reports about therapies of doubtful benefits while trying to differentiate between prophylactic measures and actual treatment methods.
Keloid fibroblasts resist ceramide-induced apoptosis by overexpression of insulin-like growth factor I receptor.
TLDR
The results suggest that keloid fibroblasts overexpressing insulin-like growth factor I receptor are resistant to apoptosis, thus allowing persistent proliferation and production of excessive extracellular matrix.
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