The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology

@inproceedings{Fiandaca2011TheUO,
  title={The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology},
  author={Massimo S. Fiandaca and Mitchel S. Berger and Krystof S. Bankiewicz},
  booktitle={Toxins},
  year={2011}
}
Liposomes have long been effective delivery vehicles for transport of toxins to peripheral cancers. The combination of convection-enhanced delivery (CED) with liposomal toxins was originally proposed to circumvent the limited delivery of intravascular liposomes to the central nervous system (CNS) due to the blood-brain-barrier (BBB). CED offers markedly improved distribution of infused therapeutics within the CNS compared to direct injection or via drug eluting polymers, both of which depend on… CONTINUE READING