The Use of Amphipols for NMR Structural Characterization of 7-TM Proteins


While amphipols have been proven useful for refolding of seven transmembrane helical (7-TM) proteins including G-protein-coupled receptors (GPCRs) and it could be shown that an amphipol environment is in principle suitable for NMR structural studies of the embedded protein, high-resolution NMR insights into amphipol refolded and isotopically labeled GPCRs… (More)
DOI: 10.1007/s00232-014-9669-5