The Use of Aminopyridines in Neurological Disorders

@article{Sedehizadeh2012TheUO,
  title={The Use of Aminopyridines in Neurological Disorders},
  author={Saam Sedehizadeh and Michael Keogh and Paul Maddison},
  journal={Clinical Neuropharmacology},
  year={2012},
  volume={35},
  pages={191–200}
}
AbstractAminopyridines are members of a family of monoamino and diamino derivatives of pyridine, and their principal mechanism of action is dose-dependent blockade of voltage-gated potassium channels, in particular, fast voltage-gated potassium channels. To date, only 2 main broad-spectrum potassium channel blockers, 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP), have been used as investigational new drugs in various neurological diseases. More recently, licensed versions of these… 
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