The Use Of A Calcium‐Channel Blocker, Nicardipine, For Severely Asphyxiated Newborn Infants

@article{Levene1990TheUO,
  title={The Use Of A Calcium‐Channel Blocker, Nicardipine, For Severely Asphyxiated Newborn Infants},
  author={Malcolm I. Levene and Neil A. Gibson and Alan Charles Fenton and E. Papathoma and David B. Barnett},
  journal={Developmental Medicine \& Child Neurology},
  year={1990},
  volume={32}
}
A continuous infusion of nicardipine was given to four severely asphyxiated fullterm infants who were at high risk for adverse outcome and had abnormal cerebral Doppler haemodynamic studies. The heart rate increased in all four infants and mean arterial blood pressure (MAP) fell in three. Two infants had a sudden and marked fall in MAP, together with severe impairment of skin blood‐flow and a concurrent fall in cerebral blood‐flow velocity. The serum level of nicardipine was <40ng/mL in all… 
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References

SHOWING 1-10 OF 40 REFERENCES
Cardiogenic shock associated with perinatal asphyxia in preterm infants.
CEREBRAL ARTERY DOPPLER ULTRASONOGRAPHY FOR PREDICTION OF OUTCOME AFTER PERINATAL ASPHYXIA
Beagle pup model of perinatal asphyxia: nimodipine studies.
TLDR
Although nimodipine may be shown to improve neurologic outcome in asphyxiated newborn infants, the limits of this study do not show the mechanism to be that of improving CBF.
Postasphyxial Cerebral Survival in Newborn Sheep after Treatment with Oxygen Free Radical Scavengers and a Calcium Antagonist
TLDR
It is concluded that part of the brain damage in connection with acute, severe asphyxia may be inflicted by oxygen-derived free radicals released during the reoxygenation phase after resuscitation and that oxygen- derived free radical scavengers and calcium channel blockers may find a place in cardiopulmonary resuscitation.
The Effects of a Calcium Antagonist (Nimodipine) on Basal Cerebral Blood Flow and Reactivity to Various Agonists
TLDR
Results suggest that nimodipine may be a relatively selective cerebrovascular dilator and reduce the cerebral reactivity to altered PCO2.
Effect of the Calcium Antagonist, Nimodipine, on Cerebral Blood Flow and Metabolism in the Primate
  • A. Harper, L. Craigen, S. Kazda
  • Medicine, Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1981
TLDR
The evidence suggests that nimodipine has no effect on cerebral metabolism but increases CBF, particularly after disruption of the blood-brain barrier.
The incidence and severity of post-asphyxial encephalopathy in full-term infants.
Calcium blockers in cerebral resuscitation.
TLDR
It is suggested that calcium entry blockers can maintain regional cerebral cortical blood flow and may have a significant role in cerebral resuscitation following cardiac arrest.
Effect of flunarizine on canine cerebral cortical blood flow and vascular resistance post cardiac arrest.
Improved short-term neurological recovery with flunarizine in a canine model of cardiac arrest.
...
1
2
3
4
...