The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans
@article{Dietz2007TheUD, title={The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans}, author={L. Dietz and A. Glaz-Sandberg and H. Nguyen and G. Skopp and G. Mikus and R. Aderjan}, journal={Therapeutic Drug Monitoring}, year={2007}, volume={29}, pages={368-372} }
The objective of this study was to investigate the fraction of an administered dose of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THCCOOH) that is actually excreted into urine and to determine its urinary half-life independent of the parent compound. Ten healthy, male marijuana nonusers who were enrolled in the study were administered a single dose of 5 mg THCCOOH by the intravenous route. Urine specimens were collected up to 96 hours after administration. Samples were extracted before and… CONTINUE READING
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References
SHOWING 1-10 OF 49 REFERENCES
Urinary excretion half-life of 11-nor-9-carboxy-delta9-tetrahydrocannabinol in humans.
- Chemistry, Medicine
- Therapeutic drug monitoring
- 1998
- 77
Urinary excretion of 11-nor-9-carboxy-delta9-tetrahydrocannabinol and cannabinoids in frequent and infrequent drug users.
- Medicine, Chemistry
- Journal of analytical toxicology
- 1999
- 86
- PDF
Urinary Pharmacokinetics of 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol after Controlled Oral Δ9-Tetrahydrocannabinol Administration
- Chemistry
- 2004
- 29
- PDF
Stability of 11-nor-delta(9)-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry.
- Chemistry, Medicine
- Clinical chemistry
- 2002
- 70
- PDF
The metabolism of delta 9-tetrahydrocannabinol and related cannabinoids in man.
- Medicine
- Journal of clinical pharmacology
- 1981
- 37
Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses.
- Chemistry, Medicine
- Drug metabolism and disposition: the biological fate of chemicals
- 1986
- 48
Tolerance and disposition of tetrahydrocannabinol in man.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1980
- 190
- Highly Influential
Urinary elimination half-life of delta-1-tetrahydrocannabinol-7-oic acid in heavy marijuana users after smoking.
- Chemistry, Medicine
- NIDA research monograph
- 1989
- 11
Cannabinoids in humans. II. The influence of three methods of hydrolysis on the concentration of THC and two metabolites in urine.
- Chemistry, Medicine
- Journal of analytical toxicology
- 1995
- 83
Cannabinoids in humans. I. Analysis of delta 9-tetrahydrocannabinol and six metabolites in plasma and urine using GC-MS.
- Chemistry, Medicine
- Journal of analytical toxicology
- 1995
- 75