The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans

@article{Dietz2007TheUD,
  title={The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans},
  author={L. Dietz and A. Glaz-Sandberg and H. Nguyen and G. Skopp and G. Mikus and R. Aderjan},
  journal={Therapeutic Drug Monitoring},
  year={2007},
  volume={29},
  pages={368-372}
}
  • L. Dietz, A. Glaz-Sandberg, +3 authors R. Aderjan
  • Published 2007
  • Chemistry, Medicine
  • Therapeutic Drug Monitoring
    • The objective of this study was to investigate the fraction of an administered dose of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THCCOOH) that is actually excreted into urine and to determine its urinary half-life independent of the parent compound. Ten healthy, male marijuana nonusers who were enrolled in the study were administered a single dose of 5 mg THCCOOH by the intravenous route. Urine specimens were collected up to 96 hours after administration. Samples were extracted before and… CONTINUE READING
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    13 Citations
    Background Citations
    1
    Methods Citations
    1
    13 Citations
    Citation Type

    Citation Type

    Disposition and enterohepatic circulation of intravenously administered 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in serum and urine in healthy human subjects
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    Tetrahydrocannabinol in Serum and Urine in Healthy Human
    Minimal Physiologically Based Pharmacokinetic Model of Intravenously and Orally Administered Delta-9-Tetrahydrocannabinol in Healthy Volunteers
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    Accurate identification and quantification of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid in urine drug testing: evaluation of a direct high efficiency liquid chromatographic-mass spectrometric method.
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    Development and validation of a method for 11-nor-9-carboxy-delta9-tetrahydrocannabinol quantification using gas chromatography coupled to triple quadrupole mass spectrometry
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    Urinary cannabinoid disposition in occasional and frequent smokers: is THC-glucuronide in sequential urine samples a marker of recent use in frequent smokers?
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    Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography–tandem mass spectrometry
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    New catalytic ultrasound method for derivatization of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in urine, with analysis by GC-MS/MS
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    Oral fluid cannabinoids in chronic, daily Cannabis smokers during sustained, monitored abstinence.
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    • PDF

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