The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans

@article{Dietz2007TheUD,
  title={The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans},
  author={Lisa Dietz and A Glaz-Sandberg and Hang T Nguyen and Gisela Skopp and Gerd Mikus and Rolf Aderjan},
  journal={Therapeutic Drug Monitoring},
  year={2007},
  volume={29},
  pages={368-372}
}
The objective of this study was to investigate the fraction of an administered dose of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THCCOOH) that is actually excreted into urine and to determine its urinary half-life independent of the parent compound. Ten healthy, male marijuana nonusers who were enrolled in the study were administered a single dose of 5 mg THCCOOH by the intravenous route. Urine specimens were collected up to 96 hours after administration. Samples were extracted before and… 
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Disposition and enterohepatic circulation of intravenously administered 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in serum and urine in healthy human subjects

In both blood and urine, detection of 11-nor-9-carboxy-Δ9-tetrahydro-cannabinol (THC-COOH) is most appropriate considering its long half-life.

Tetrahydrocannabinol in Serum and Urine in Healthy Human

Taking of remedies impairing enterohepatic circulation while/after smoking of THC may as well affect THC-COOH or its glucuronide concentrations in serum and urine, impair renal excretion and decrease their time window of detection.

Minimal Physiologically Based Pharmacokinetic Model of Intravenously and Orally Administered Delta-9-Tetrahydrocannabinol in Healthy Volunteers

The pharmacokinetics of THC and its major metabolites are characterized in healthy volunteers with known CYP2C9 status by non-compartmental analysis, compartmental modeling and minimal physiologically based pharmacokinetic (mPBPK) modeling to partially disentangle the complexity of cannabis disposition in humans.

Accurate identification and quantification of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid in urine drug testing: evaluation of a direct high efficiency liquid chromatographic-mass spectrometric method.

Development and validation of a method for 11-nor-9-carboxy-delta9-tetrahydrocannabinol quantification using gas chromatography coupled to triple quadrupole mass spectrometry

This paper presents a method for 11-nor-9-carboxy-delta9-tetrahydrocanabinol (THC-COOH) quantification from urine samples, for doping control purposes. The method involves gas chromatography coupled…

Cannabinoid concentrations in spot serum samples 24-48 hours after discontinuation of cannabis smoking.

The present findings appear to indicate that low levels of THC, or of THC along with OH-THC, may not unequivocally prove a very recent use of cannabis.

Urinary cannabinoid disposition in occasional and frequent smokers: is THC-glucuronide in sequential urine samples a marker of recent use in frequent smokers?

These controlled urinary cannabinoid data provide a possible means of identifying recent cannabis intake in cannabis smokers' urine within a short collection time frame after smoking.

Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography–tandem mass spectrometry

The first method for quantifying cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography–tandem mass spectrometry (LC–MS/MS) was developed and validated and should be useful for quantify cannabinoids in wholeBlood and further investigating cannabinoid glucurides as markers of recent cannabis intake.

New catalytic ultrasound method for derivatization of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in urine, with analysis by GC-MS/MS

The use of imidazole as a catalyst, together with ultrasonication, reduced the reaction time to 5 min and increased the efficiency of derivatization of THCCOOH, compared with the conventional method.

Oral fluid cannabinoids in chronic, daily Cannabis smokers during sustained, monitored abstinence.

Inclusion of multiple cannabinoid cutoffs accounted for residual cannabinoid excretion in OF from chronic, daily cannabis smokers and could reduce the potential for positive test results from passive cannabis smoke exposure and lead to greatly improved test interpretation.

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