The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans

  title={The Urinary Disposition of Intravenously Administered 11-Nor-9-carboxy-delta-9-Tetrahydrocannabinol in Humans},
  author={L. Dietz and A. Glaz-Sandberg and H. Nguyen and G. Skopp and G. Mikus and R. Aderjan},
  journal={Therapeutic Drug Monitoring},
  • L. Dietz, A. Glaz-Sandberg, +3 authors R. Aderjan
  • Published 2007
  • Chemistry, Medicine
  • Therapeutic Drug Monitoring
  • The objective of this study was to investigate the fraction of an administered dose of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THCCOOH) that is actually excreted into urine and to determine its urinary half-life independent of the parent compound. Ten healthy, male marijuana nonusers who were enrolled in the study were administered a single dose of 5 mg THCCOOH by the intravenous route. Urine specimens were collected up to 96 hours after administration. Samples were extracted before and… CONTINUE READING
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