The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration

@inproceedings{Perri2015TheUP,
  title={The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration},
  author={Emma R. Perri and Colleen J. Thomas and Sonam Parakh and Damian M. S. Spencer and Julie D. Atkin},
  booktitle={Front. Cell Dev. Biol.},
  year={2015}
}
The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite having different clinical manifestations, these disorders share similar pathology; an accumulation of misfolded proteins in neurons and subsequent disruption to cellular proteostasis. The endoplasmic reticulum (ER) is an important component of proteostasis, and when the accumulation of misfolded proteins occurs… CONTINUE READING
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Peptide disulfide RKCGCFF facilitates oxidative protein refolding by mimicking protein disulfide isomerase

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