The Unfolded Protein Response and Diabetic Retinopathy

  title={The Unfolded Protein Response and Diabetic Retinopathy},
  author={Jacey Hongjie Ma and Josh J Wang and Sarah Xin Zhang},
  booktitle={Journal of diabetes research},
Diabetic retinopathy, a common complication of diabetes, is the leading cause of blindness in adults. Diabetes chronically damages retinal blood vessels and neurons likely through multiple pathogenic pathways such as oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. To relieve ER stress, the cell activates an adaptive mechanism known as the unfolded protein response (UPR). The UPR coordinates the processes of protein synthesis, protein folding, and degradation to ensure… CONTINUE READING
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