The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

@article{Walter2011TheUP,
  title={The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation},
  author={Peter Walter and David Ron},
  journal={Science},
  year={2011},
  volume={334},
  pages={1081 - 1086}
}
The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled proteins advance from the ER to the cell surface. To ascertain fidelity in protein folding, cells regulate the protein-folding capacity in the ER according to need. The ER responds to the burden of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways, collectively termed the… 
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