The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases

  title={The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases},
  author={Jason H. Moore},
  journal={Human Heredity},
  pages={73 - 82}
  • J. Moore
  • Published 1 November 2003
  • Biology
  • Human Heredity
There is increasing awareness that epistasis or gene-gene interaction plays a role in susceptibility to common human diseases. In this paper, we formulate a working hypothesis that epistasis is a ubiquitous component of the genetic architecture of common human diseases and that complex interactions are more important than the independent main effects of any one susceptibility gene. This working hypothesis is based on several bodies of evidence. First, the idea that epistasis is important is not… 

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