The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV

  title={The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV},
  author={N. Manel and F. Kim and S. Kinet and N. Taylor and M. Sitbon and Jean-Luc Battini},
  • N. Manel, F. Kim, +3 authors Jean-Luc Battini
  • Published 2003
  • Biology, Medicine
  • Cell
  • The human T cell leukemia virus (HTLV) is associated with leukemia and neurological syndromes. The physiopathological effects of HTLV envelopes are unclear and the identity of the receptor, present on all vertebrate cell lines, has been elusive. We show that the receptor binding domains of both HTLV-1 and -2 envelope glycoproteins inhibit glucose transport by interacting with GLUT-1, the ubiquitous vertebrate glucose transporter. Receptor binding and HTLV envelope-driven infection are… CONTINUE READING
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