The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV

@article{Manel2003TheUG,
  title={The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV},
  author={N. Manel and F. Kim and S. Kinet and N. Taylor and M. Sitbon and Jean-Luc Battini},
  journal={Cell},
  year={2003},
  volume={115},
  pages={449-459}
}
  • N. Manel, F. Kim, +3 authors Jean-Luc Battini
  • Published 2003
  • Biology, Medicine
  • Cell
  • The human T cell leukemia virus (HTLV) is associated with leukemia and neurological syndromes. The physiopathological effects of HTLV envelopes are unclear and the identity of the receptor, present on all vertebrate cell lines, has been elusive. We show that the receptor binding domains of both HTLV-1 and -2 envelope glycoproteins inhibit glucose transport by interacting with GLUT-1, the ubiquitous vertebrate glucose transporter. Receptor binding and HTLV envelope-driven infection are… CONTINUE READING
    382 Citations
    HTLV envelopes and their receptor GLUT1, the ubiquitous glucose transporter: a new vision on HTLV infection?
    • 19
    • PDF
    Expression of Glucose Transporter 1 Confers Susceptibility to Human T-Cell Leukemia Virus Envelope-Mediated Fusion
    • 48
    • Highly Influenced
    • PDF
    Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells
    • 58
    GLUT1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1
    • 53
    • PDF
    Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry
    • 155
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 86 REFERENCES
    The HTLV receptor is a widely expressed protein.
    • 63
    The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis.
    • 79
    • PDF
    HTLV-1-induced cell fusion is limited at two distinct steps in the fusion pathway after receptor binding.
    • 13
    • PDF
    Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton.
    • 187
    Facilitative glucose transporters.
    • M. Mueckler
    • Medicine, Biology
    • European journal of biochemistry
    • 1994
    • 1,028
    • Highly Influential
    Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation.
    • 48
    • Highly Influential
    • PDF
    Influence of transmembrane domains on the fusogenic abilities of human and murine leukemia retrovirus envelopes.
    • 44
    • PDF