The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy

@article{Speese2003TheUP,
  title={The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy},
  author={Sean D. Speese and Nick Trotta and Chris K Rodesch and Bharathi Aravamudan and Kendal Broadie},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={899-910}
}
BACKGROUND The ubiquitin proteasome system (UPS) mediates regulated protein degradation and provides a mechanism for closely controlling protein abundance in spatially restricted domains within cells. We hypothesized that the UPS may acutely determine the local concentration of key regulatory proteins at neuronal synapses as a means for locally modulating synaptic efficacy and the strength of neurotransmission communication. RESULTS We investigated this hypothesis at the Drosophila… CONTINUE READING

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