The ULK1 complex: sensing nutrient signals for autophagy activation.

@article{Wong2013TheUC,
  title={The ULK1 complex: sensing nutrient signals for autophagy activation.},
  author={P Wong and Cindy Puente and Ian G Ganley and Xuejun Jiang},
  journal={Autophagy},
  year={2013},
  volume={9 2},
  pages={124-37}
}
The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating signals from upstream sensors such as MTOR and AMPK and transducing them to the downstream autophagy pathway. Much progress has been made in the last few years in understanding the mechanisms by which the complex is regulated through protein-protein interactions and post-translational modifications, providing insights into how the cell modulates autophagy, particularly in response to nutrient status. However… CONTINUE READING