Corpus ID: 8012730

The U 11 / U 12 snRNP 65 K protein acts as a molecular bridge , binding the U 12 snRNA and U 1159 K protein

@inproceedings{Benecke2005TheU1,
  title={The U 11 / U 12 snRNP 65 K protein acts as a molecular bridge , binding the U 12 snRNA and U 1159 K protein},
  author={H. Benecke and R. L{\"u}hrmann and C. Will},
  year={2005}
}
U11 and U12 interact cooperatively with the 50 splice site and branch site of pre-mRNA as a stable preformed di-snRNP complex, thereby bridging the 50 and 30 ends of the intron within the U12-dependent prespliceosome. To identify proteins contributing to di-snRNP formation and intron bridging, we investigated protein–protein and protein–RNA interactions between components of the U11/ U12 snRNP. We demonstrate that the U11/U12-65K protein possesses dual binding activity, interacting directly… CONTINUE READING
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References

SHOWING 1-10 OF 43 REFERENCES
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
  • 135
  • PDF
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins
  • 142
  • PDF
Functional interaction of a novel 15.5kD[U4/U6·U5] tri‐snRNP protein with the5′ stem–loop of U4 snRNA
  • 190
  • PDF
A novel U2 and U11/U12 snRNP protein that associates with the pre‐mRNA branch site
  • 169
  • PDF
Crystal structure of the spliceosomal U2B″–U2A′ protein complex bound to a fragment of U2 small nuclear RNA
  • 333
The low-abundance U11 and U12 small nuclear ribonucleoproteins (snRNPs) interact to form a two-snRNP complex.
  • 80
  • PDF
A Novel Spliceosome Containing U11, U12, and U5 snRNPs Excises a Minor Class (AT–AC) Intron In Vitro
  • 308