The Tyrosine Phosphatase SHP2 Modulates MAP Kinase p38 and Caspase 1 and 3 to Foster Neuronal Survival

1. The Src homology protein tyrosine phosphatase SHP2 is associated with cytoskeletal maintenance, cell division, and cell differentiation, but the role of SHP2 during central nervous system injury requires further definition. We therefore characterized the role of SHP2 during nitric oxide (NO)-induced programmed cell death (PCD). 2. Employing primary… CONTINUE READING