The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection

@inproceedings{Belluz2016TheTT,
  title={The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection},
  author={Lisa Del Bel Belluz and Riccardo Guidi and Vassilis Georgoulias and Laura Jane. Levi and Boris Mihaljevi{\'c} and Syed Fazle Rouf and Marie Wrande and Marco Candela and Silvia Turroni and Claudia Nastasi and Clarissa Consolandi and Clelia Peano and Toma Tebaldi and Gabriella Viero and Vassilis G Gorgoulis and Thorbj{\o}rn Krejsgaard and Mikael Rhen and Teresa Frisan},
  booktitle={PLoS pathogens},
  year={2016}
}
Bacterial genotoxins, produced by several Gram-negative bacteria, induce DNA damage in the target cells. While the responses induced in the host cells have been extensively studied in vitro, the role of these effectors during the course of infection remains poorly characterized. To address this issue, we assessed the effects of the Salmonella enterica genotoxin, known as typhoid toxin, in in vivo models of murine infection. Immunocompetent mice were infected with isogenic S. enterica, serovar… CONTINUE READING

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Emerging insights into the biology of typhoid toxin.

  • Current opinion in microbiology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 82 REFERENCES

Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin.

Jeongmin Song, Xiang Gao, Jorge E. Galán
  • Nature
  • 2013
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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