The Type VII Secretion System of Staphylococcus.

  title={The Type VII Secretion System of Staphylococcus.},
  author={Lisa Bowman and Tracy Palmer},
  journal={Annual review of microbiology},
The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the ess locus. T7 substrate recognition and protein transport are mediated by EssC, a membrane-bound multidomain ATPase. Four EssC sequence variants have been identified across S. aureus strains, each accompanied by a specific suite of substrate proteins. The ess genes are upregulated during persistent infection, and the secretion system contributes to virulence in disease models. It also plays a key role in… 

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