The Type V Transforming Growth Factor β Receptor Is the Putative Insulin-like Growth Factor-binding Protein 3 Receptor*

@article{Leal1997TheTV,
  title={The Type V Transforming Growth Factor $\beta$ Receptor Is the Putative Insulin-like Growth Factor-binding Protein 3 Receptor*},
  author={Sandra M Leal and Qianjin Liu and Shuan Shian Huang and Jung San Huang},
  journal={The Journal of Biological Chemistry},
  year={1997},
  volume={272},
  pages={20572 - 20576}
}
Insulin-like growth factor-binding protein 3 (IGFBP-3) has been shown to inhibit cell growth by IGF-dependent and -independent mechanisms. The putative cell-surface IGFBP-3 receptor that mediates the IGF-independent growth inhibition has not been identified. Here we show that recombinant human IGFBP-3 inhibits125I-transforming growth factor (TGF)-β1 binding to the type V TGF-β receptor (M r 400,000) in mink lung epithelial cells. We also demonstrate that the ∼400-kDa125I-IGFBP-3 affinity… 

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