The Type III Secretion Effector NleE Inhibits NFk B Activation

  title={The Type III Secretion Effector NleE Inhibits NFk B Activation},
  author={Chen Nadler and Kobi Baruch and Simi Kobi and Erez Mills and Gili Haviv and Marganit Farago and Irit Alkalay and Sina Bartfeld and Thomas F. Meyer and Yinon Ben-Neriah and Ilan Rosenshine},
The complex host-pathogen interplay involves the recognition of the pathogen by the host’s innate immune system and countermeasures taken by the pathogen. Detection of invading bacteria by the host leads to rapid activation of the transcription factor NF-kB, followed by inflammation and eradication of the intruders. In response, some pathogens, including enteropathogenic Escherichia coli (EPEC), acquired means of blocking NF-kB activation. We show that inhibition of NF-kB activation by EPEC… CONTINUE READING

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