The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

@inproceedings{Newton2010TheTI,
  title={The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65},
  author={Hayley J Newton and Jaclyn S Pearson and Luminita Badea and Michelle Nadeau Kelly and Mark R. Lucas and Gavan Holloway and Kylie M Wagstaff and Michelle A. Dunstone and Joan Sloan and James C. Whisstock and J. Kaper and Roy M Robins-Browne and David A Jans and Gad Frankel and Alan David Phillips and Barbara S Coulson and Elizabeth L Hartland},
  booktitle={PLoS pathogens},
  year={2010}
}
Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli (EPEC) and OspZ from Shigella, blocked translocation of the p65 subunit of the transcription factor, NF-kappaB, to the host cell nucleus. NF-kappaB inhibition by NleE was associated with decreased IL-8 expression in EPEC-infected intestinal epithelial cells. Ectopically expressed NleE also blocked… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

NF-kappaB regulation in the immune system.

  • Nature reviews. Immunology
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Genome sequence of enterohaemorrhagic Escherichia coli O157:H7

NT Perna, G Plunkett, +3 authors JD Glasner
  • Nature
  • 2001
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

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