The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

@article{Newton2010TheTI,
  title={The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-$\kappa$B p65},
  author={Hayley J. Newton and Jaclyn S Pearson and Luminita Badea and Michelle N. Kelly and Mark Lucas and Gavan Holloway and Kylie M. Wagstaff and Michelle A. Dunstone and Joan Sloan and James C. Whisstock and James B. Kaper and Roy M Robins-Browne and David Andrew Jans and Gad Frankel and Alan D. Phillips and Barbara S. Coulson and Elizabeth L. Hartland},
  journal={PLoS Pathogens},
  year={2010},
  volume={6}
}
Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli (EPEC) and OspZ from Shigella, blocked translocation of the p65 subunit of the transcription factor, NF-κB, to the host cell nucleus. NF-κB inhibition by NleE was associated with decreased IL-8 expression in EPEC-infected intestinal epithelial cells. Ectopically expressed NleE also blocked nuclear… Expand
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It is concluded that NleC is a type III effector protease that degrades NF‐κB thereby contributing the arsenal of bacterial effectors that inhibit innate immune activation. Expand
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TLDR
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TLDR
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TLDR
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Attaching and Effacing Bacterial Effector NleC Suppresses Epithelial Inflammatory Responses by Inhibiting NF-κB and p38 Mitogen-Activated Protein Kinase Activation
TLDR
Testing an array of EPEC mutants, it is identified the non-LEE-encoded effector C (NleC) as also suppressing IL-8 release, which advances the understanding of how A/E pathogens subvert host inflammatory responses. Expand
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