The Two-sample Problem for Failure Rates Depending on a Continuous Mark : An Application to Vaccine Efficacy

  • Peter B. G ILBERT
The efficacy of an HIV vaccine to prevent infection is likely to depend on the genetic variation of the exposing virus. This paper addresses the problem of using data on the HIV sequences that infect vaccine efficacy trial participants to 1) test for vaccine efficacy more powerfully than procedures that ignore the sequence data; and 2) evaluate the… CONTINUE READING