The Two Membrane Isoforms of Human IgE Assemble into Functionally Distinct B Cell Antigen Receptors

@article{Batista1996TheTM,
  title={The Two Membrane Isoforms of Human IgE Assemble into Functionally Distinct B Cell Antigen Receptors},
  author={Facundo D Batista and Shubha Anand and Gianni Presani and Dimitar G Efremov and Oscar R Burrone},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={2197 - 2206}
}
The human C epsilon gene expresses two membrane IgE heavy chain mRNAs which differ in the sequence that encodes their extracellular membrane-proximal domain. In the long IgE isoform (mLIgE), this domain contains a stretch of 52 amino acids which are absent in the short variant (mSIgE). We have now generated B cell transfectoma cell lines that express these two isoforms and show that both types of mIgE form functional B cell antigen receptors (BCR). Both receptors associate with the Ig-alpha/Ig… CONTINUE READING

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