The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator.

@article{Conlan1999TheTP,
  title={The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator.},
  author={R Steven Conlan and Niki Gounalaki and Pantelis Hatzis and Dimitris Tzamarias},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 1},
  pages={205-10}
}
Cyc8(Ssn6)-Tup1, a general co-repressor complex, is recruited to promoter DNA via interactions with DNA-binding regulatory proteins and inhibits the transcription of many different yeast genes. Previous studies have established that repression function of the complex is performed by one subunit of the complex, the Tup1 protein, and requires specific components of the RNA polymerase II holoenzyme such as Sin4 and Rgr1. In this study we test the transcriptional activity of the Cyc8 subunit using… CONTINUE READING

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