The Tumor Suppressor DAP Kinase Is a Target of RSK-Mediated Survival Signaling

@article{Anjum2005TheTS,
  title={The Tumor Suppressor DAP Kinase Is a Target of RSK-Mediated Survival Signaling},
  author={Rana Anjum and Philippe P Roux and Bryan A. Ballif and Steven P Gygi and John Blenis},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={1762-1767}
}
The viability of vertebrate cells depends on a complex signaling interplay between survival factors and cell-death effectors. Subtle changes in the equilibrium between these regulators can result in abnormal cell proliferation or cell death, leading to various pathological manifestations. Death-associated protein kinase (DAPK) is a multidomain calcium/calmodulin (CaM)-dependent Ser/Thr protein kinase with an important role in apoptosis regulation and tumor suppression. The molecular signaling… CONTINUE READING

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