The Tumor Microenvironment in Colorectal Carcinogenesis

  title={The Tumor Microenvironment in Colorectal Carcinogenesis},
  author={Vijay G R Peddareddigari and Dingzhi Wang and Raymond N. Dubois},
  journal={Cancer Microenvironment},
Colorectal cancer is the second leading cause of cancer-related mortality in the United States. Therapeutic developments in the past decade have extended life expectancy in patients with metastatic disease. However, metastatic colorectal cancers remain incurable. Numerous agents that were demonstrated to have significant antitumor activity in experimental models translated into disappointing results in extending patient survival. This has resulted in more attention being focused on the… CONTINUE READING