The Trypanosoma brucei flagellum: moving parasites in new directions.

  title={The Trypanosoma brucei flagellum: moving parasites in new directions.},
  author={Katherine S. Ralston and Zakayi P Kabututu and Jason H. Melehani and Michael Oberholzer and Kent L. Hill},
  journal={Annual review of microbiology},
African trypanosomes are devastating human and animal pathogens. Trypanosoma brucei rhodesiense and T. b. gambiense subspecies cause the fatal human disease known as African sleeping sickness. It is estimated that several hundred thousand new infections occur annually and the disease is fatal if untreated. T. brucei is transmitted by the tsetse fly and alternates between bloodstream-form and insect-form life cycle stages that are adapted to survive in the mammalian host and the insect vector… CONTINUE READING
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