The Trp64Arg mutation of the beta3-adrenergic receptor is associated with hyperglycemia and current body mass index in Jamaican women.

@article{McFarlaneAnderson1998TheTM,
  title={The Trp64Arg mutation of the beta3-adrenergic receptor is associated with hyperglycemia and current body mass index in Jamaican women.},
  author={Norma D. McFarlane-Anderson and F I Bennett and Rainford Jonathan Wilks and Simon D Howell and Christine Newsome and Kennedy Cruickshank and Terrence E. Forrester},
  journal={Metabolism: clinical and experimental},
  year={1998},
  volume={47 5},
  pages={617-21}
}
The Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR) has been linked to earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), insulin resistance, abdominal obesity, and an increased capacity to gain weight in some European and Japanese populations. We studied the prevalence of the mutation and its association with NIDDM and obesity in our population, in which both rates are high, especially in women. The frequency of the homozygous mutation was 1.53%, and of the Arg… CONTINUE READING

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