The Tritiated Water Skin Barrier Integrity Test: Considerations for Acceptance Criteria with and Without 14C-Octanol

Abstract

A study was designed to assess barrier integrity simultaneously using separate compounds (probes) for polar and non-polar pathways through the skin, 3H2O and 14C-octanol, respectively; and to determine whether the two probe approach could better define barrier integrity. A 5-min dose of water containing 3H2O and 14C -octanol was applied to ex vivo human… (More)
DOI: 10.1007/s11095-016-2057-3

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@article{Lehman2016TheTW, title={The Tritiated Water Skin Barrier Integrity Test: Considerations for Acceptance Criteria with and Without 14C-Octanol}, author={Paul A. Lehman and Kacie Beatch and Sam G. Raney and Thomas J. Franz}, journal={Pharmaceutical Research}, year={2016}, volume={34}, pages={217-228} }