The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding

  title={The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding},
  author={Karl Kornacker and Morten Rye and Tony H{\aa}ndstad and Finn Drabl\os},
  booktitle={BMC Bioinformatics},
Chromatin immunoprecipitation combined with high-throughput sequencing (ChIP-Seq) is the most frequently used method to identify the binding sites of transcription factors. Active binding sites can be seen as peaks in enrichment profiles when the sequencing reads are mapped to a reference genome. However, the profiles are normally noisy, making it challenging to identify all significantly enriched regions in a reliable way and with an acceptable false discovery rate. We present the Triform… CONTINUE READING
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