The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding

@article{Kornacker2012TheTA,
  title={The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding},
  author={K. Kornacker and M. Rye and T. H{\aa}ndstad and F. Drabl{\o}s},
  journal={BMC Bioinformatics},
  year={2012},
  volume={13},
  pages={176 - 176}
}
  • K. Kornacker, M. Rye, +1 author F. Drabløs
  • Published 2012
  • Computer Science, Biology, Medicine
  • BMC Bioinformatics
  • BackgroundChromatin immunoprecipitation combined with high-throughput sequencing (ChIP-Seq) is the most frequently used method to identify the binding sites of transcription factors. Active binding sites can be seen as peaks in enrichment profiles when the sequencing reads are mapped to a reference genome. However, the profiles are normally noisy, making it challenging to identify all significantly enriched regions in a reliable way and with an acceptable false discovery rate.ResultsWe present… CONTINUE READING
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