The Tregs' world according to GARP.

  title={The Tregs' world according to GARP.},
  author={Manuela Battaglia and Maria Grazia Roncarolo},
  journal={European journal of immunology},
  volume={39 12},
Naturally occurring CD4+CD25(high) regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despite the important function of nTreg, the underlying molecular mechanisms of nTreg-mediated suppression are far from defined. Previous studies have demonstrated that the TGF-beta… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…