The Tregs' world according to GARP.

@article{Battaglia2009TheTW,
  title={The Tregs' world according to GARP.},
  author={Manuela Battaglia and Maria Grazia Roncarolo},
  journal={European journal of immunology},
  year={2009},
  volume={39 12},
  pages={3296-300}
}
Naturally occurring CD4+CD25(high) regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despite the important function of nTreg, the underlying molecular mechanisms of nTreg-mediated suppression are far from defined. Previous studies have demonstrated that the TGF-beta… CONTINUE READING

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