The Transport of Choline

@article{Lockman2002TheTO,
  title={The Transport of Choline},
  author={Paul R. Lockman and David D. Allen},
  journal={Drug Development and Industrial Pharmacy},
  year={2002},
  volume={28},
  pages={749 - 771}
}
  • P. Lockman, D. D. Allen
  • Published 1 January 2002
  • Biology, Chemistry
  • Drug Development and Industrial Pharmacy
ABSTRACT Choline has many physiological functions throughout the body that are dependent on its available local supply. However, since choline is a charged hydrophilic cation, transport mechanisms are required for it to cross biological membranes. Choline transport is required for cellular membrane construction and is the rate-limiting step for acetylcholine production. Transport mechanisms include: (1) sodium-dependent high-affinity uptake mechanism in synaptosomes, (2) sodium-independent low… 
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