The Transforming Growth Factor-Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia / Reperfusion Injury

@inproceedings{Kempf2006TheTG,
  title={The Transforming Growth Factor-Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia / Reperfusion Injury},
  author={T. Kempf and Matthias Eden and Jens Strelau and M. Naguib and Christian Tobias Willenbockel and Joern Tongers and Joerg Heineke and Daniel Kotlarz and J Xu and Jeffery D Molkentin and Hans W N Niessen and Helmut Drexler and Kai C. Wollert},
  year={2006}
}
Data from the Women’s Health Study show that serum levels of growth-differentiation factor-15 (GDF-15), a distant member of the transforming growth factorsuperfamily, are an independent risk indicator for adverse cardiovascular events. However, the cellular sources, upstream regulators, and functional effects of GDF-15 in the cardiovascular system have not been elucidated. We have identified GDF-15 by cDNA expression array analysis as a gene that is strongly upregulated by nitrosative stress in… CONTINUE READING

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