The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling


The bacterial chromosome is compacted in a manner optimal for DNA transactions to occur. The degree of compaction results from the level of DNA-supercoiling and the presence of nucleoid-binding proteins. DNA-supercoiling is homeostatically maintained by the opposing activities of relaxing DNA topoisomerases and negative supercoil-inducing DNA gyrase. DNA… (More)
DOI: 10.3389/fmicb.2017.01447


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