The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours

@inproceedings{Rosario2012TheTT,
  title={The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours},
  author={Roseanne Rosario and Hiromitsu Araki and Cristin G. Print and Andrew N Shelling},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all GCTs examined. This investigation aims to identify the pathogenicity of mutant FOXL2 by studying its altered transcriptional targets. METHODS The expression of mutant FOXL2 was reduced in the GCT cell line KGN, and wildtype and mutant FOXL2 were… CONTINUE READING