The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours


BACKGROUND Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all GCTs examined. This investigation aims to identify the pathogenicity of mutant FOXL2 by studying its altered… (More)
DOI: 10.1371/journal.pone.0046270


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