The Transcriptional Inhibitors , Actinomycin D and a-Amanitin , Activate the HIV-1 Promoter and Favor Phosphorylation of the RNA Polymerase II C-terminal Domain *

@inproceedings{Cass1999TheTI,
  title={The Transcriptional Inhibitors , Actinomycin D and a-Amanitin , Activate the HIV-1 Promoter and Favor Phosphorylation of the RNA Polymerase II C-terminal Domain *},
  author={C{\'e}line Cass{\'e} and Federico Giannoni and Van Trung Nguyen and M M Dubois and Olivier Bensaude},
  year={1999}
}
Actinomycin D and a-amanitin are commonly used to inhibit transcription. Unexpectedly, however, the transcription of the human immunodeficiency virus (HIV-1) long terminal repeats (LTR) is shown to be activated at the level of elongation, in human and murine cells exposed to these drugs, whereas the Rous sarcoma virus LTR, the human cytomegalovirus immediate early gene (CMV), and the HSP70 promoters are repressed. Activation of the HIV LTR is independent of the NFkB and TAR sequences and… CONTINUE READING