The Transcription Factor REST Is Lost in Aggressive Breast Cancer

  title={The Transcription Factor REST Is Lost in Aggressive Breast Cancer},
  author={Matthew P. Wagoner and Kearney T W Gunsalus and Barry A. Schoenike and Andrea L. Richardson and Andreas Friedl and Avtar Roopra},
  booktitle={PLoS genetics},
The function of the tumor suppressor RE1 silencing transcription factor (REST) is lost in colon and small cell lung cancers and is known to induce anchorage-independent growth in human mammary epithelial cells. However, nothing is currently known about the role of this tumor suppressor in breast cancer. Here, we test the hypothesis that loss of REST function plays a role in breast cancer. To assay breast tumors for REST function, we developed a 24-gene signature composed of direct targets of… CONTINUE READING
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