The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals

@article{Logan1998TheTF,
  title={The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals},
  author={M. Logan and S. Pag{\'a}n-Westphal and D. M. Smith and L. Paganessi and C. Tabin},
  journal={Cell},
  year={1998},
  volume={94},
  pages={307-317}
}
  • M. Logan, S. Pagán-Westphal, +2 authors C. Tabin
  • Published 1998
  • Biology, Medicine
  • Cell
  • The mechanism by which asymmetric signals induce left-right-specific morphogenesis has been elusive. Pitx2 encodes a transcription factor expressed throughout the left lateral plate mesoderm and subsequently on the left side of asymmetric organs such as the heart and gut during organogenesis in the chick embryo. Pitx2 is induced by the asymmetric signals encoded by Nodal and Sonic hedgehog, and its expression is blocked by prior treatment with an antibody against Sonic hedgehog. Misexpression… CONTINUE READING
    433 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Nodal signalling and the roles of the transcription factors SnR and Pitx2 in vertebrate left–right asymmetry
    • 62
    The transcription factor Pitx2 positions the embryonic axis and regulates twinning
    • 21
    • Highly Influenced
    • PDF
    Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation.
    • 241
    • Highly Influenced
    • PDF
    Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs
    • 70
    • PDF
    Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left–right asymmetry
    • 154
    • Highly Influenced

    References

    SHOWING 1-10 OF 78 REFERENCES
    Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping.
    • 105
    A molecular pathway determining left-right asymmetry in chick embryogenesis
    • 751
    • Highly Influential
    • PDF
    Relationship between asymmetric nodal expression and the direction of embryonic turning
    • 567
    Control of Vertebrate Left-Right Asymmetry by a Snail-Related Zinc Finger Gene
    • 196
    The Transfer of Left-Right Positional Information during Chick Embryogenesis
    • 199
    Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos
    • 443