The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals

  title={The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals},
  author={M. Logan and S. Pag{\'a}n-Westphal and D. M. Smith and L. Paganessi and C. Tabin},
  • M. Logan, S. Pagán-Westphal, +2 authors C. Tabin
  • Published 1998
  • Biology, Medicine
  • Cell
  • The mechanism by which asymmetric signals induce left-right-specific morphogenesis has been elusive. Pitx2 encodes a transcription factor expressed throughout the left lateral plate mesoderm and subsequently on the left side of asymmetric organs such as the heart and gut during organogenesis in the chick embryo. Pitx2 is induced by the asymmetric signals encoded by Nodal and Sonic hedgehog, and its expression is blocked by prior treatment with an antibody against Sonic hedgehog. Misexpression… CONTINUE READING
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