The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection.

@article{Cristina2004TheTG,
  title={The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection.},
  author={Manlio Di Cristina and Paola Del Porto and Wilma Buffolano and Elisa Beghetto and Andrea Spadoni and Silvia Guglietta and Enza Piccolella and F. Felici and Nicola Gargano},
  journal={Microbes and infection},
  year={2004},
  volume={6 2},
  pages={164-71}
}
Infection of humans by Toxoplasma gondii leads to an acute systemic phase, in which tachyzoites disseminate throughout the body, followed by a chronic phase characterized by the presence of tissue cysts, containing bradyzoites, in brain, heart and skeletal muscles. This work focused on studying the antigenic regions of bradyzoite-specific proteins involved in human B- and T-cell responses. To this aim, we constructed a phage-display library of DNA fragments derived from the bradyzoite-specific… CONTINUE READING

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