The Toxicology Investigators Consortium Case Registry—the 2015 Experience

Abstract

The American College of Medical Toxicology established the Toxicology Investigators Consortium (ToxIC) Case Registry in 2010. The Registry contains all medical toxicology consultations performed at participating sites. The Registry has continued to grow since its inception, and as of December 31, 2015, contains 43,099 cases. This is the sixth annual report of the ToxIC Registry, summarizing the additional 8115 cases entered in 2015. Cases were identified by a query of the Registry for all cases entered between January 1 and December 31, 2015. Specific data reviewed for analysis included demographics (age, race, gender), source of consultation, reason for consultation, agents and agent classes involved in exposures, signs, symptoms, clinical findings, fatalities, and treatment. By the end of 2015, there were 50 active sites, consisting of 101 separate health-care facilities; 51.2 % of cases involved females. Adults between the ages of 19 and 65 made up the majority (64.2 %) of Registry cases. Caucasian race was the most commonly reported (55.6 %); 9.6 % of cases were identified as Hispanic ethnicity. Inpatient and emergency department referrals were by far the most common referral sources (92.9 %). Intentional pharmaceutical exposures remained the most frequent reason for consultation, making up 52.3 % of cases. Of these intentional pharmaceutical exposures, 69 % represented an attempt at self-harm, and 85.6 % of these were a suicide attempt. Nonopioid analgesics, sedative-hypnotics, and antidepressant agents were the most commonly reported agent classes in 2015. Almost one-third of Registry cases involved a diagnosed toxidrome (32.8 %), with a sedative-hypnotic toxidrome being the most frequently described. Significant vital sign abnormalities were recorded in 25.3 % of cases. There were 98 fatalities reported in the Registry (1.2 %). Adverse drug reactions were reported in 4.3 % of cases. Toxicological treatment was given in 65.3 % of cases, with 33.0 % receiving specific antidotal therapy. Exposure characteristics and trends overall were similar to prior years. While treatment interventions were required in the majority of cases, fatalities were rare.

DOI: 10.1007/s13181-016-0580-6

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@article{Farrugia2016TheTI, title={The Toxicology Investigators Consortium Case Registry—the 2015 Experience}, author={Lynn A. Farrugia and Sean Hyun Rhyee and Sharan L. Campleman and Anne-Michelle Ruha and Timothy Weigand and Paul M. Wax and Jeffrey A Brent and Steven A. Seifert and Adam C. Pomerleau and Ziad Kazzi and Michael Ganetsky and Michele M. Burns and Michael C. Beuhler and Joshua D. King and Steven E. Aks and Jakub Furmaga and Christopher O. Hoyte and Jerrold Blair Leikin and Rais B Vohra and Bryan S. Judge and Brad D. Riley and William Joel Meggs and Didi Bentur and Phil Moore and Spencer Greene and Daniel Edward Rusyniak and Jennifer A. Lowry and Adam D. Algren and Brian J Wolk and Michael Levine and J. N. Nogar and Mark A Kostic and David D. Gummin and Diane P. Calello and A. J. Geib and Stephanie Sophia Hernandez and Silas Smith and Lewis S . Nelson and Steven Matthew Marcus and Ronald Kirschner and Adam K. Rowden and David Vearrier and Rita Mckeever and Michelle Ruha and Anthony F. Pizon and Robert G. Hendrickson and N. J. McKeown and Brandon K. Wills and Kirk Lawrence Cumpston and Mohammed A Alhelail and Timothy J. Wiegand and E. Martin Caravati and Daniel J. Sessions and Joseph K. Maddry and Alicia Bethany Minns and Derrick D. Lung and Craig Geoffrey Smollin and Thomas Kibby and Evan S Schwarz and Samuel J. Stellpflug and Kristin M. Engebretsen and Nima Majlesi and Ross Sullivan and Tamas R Peredy and Yaron Finkelstiein and Jennifer L. Carey}, journal={Journal of Medical Toxicology}, year={2016}, volume={12}, pages={224-247} }