The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

@article{Robert2016TheTP,
  title={The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation},
  author={Thomas Robert and Anne Kathrine Nore and Cyril Brun and C. Maffre and Barbara Crimi and Vincent Guichard and H.-M. Bourbon and Bernard de Massy},
  journal={Science},
  year={2016},
  volume={351},
  pages={943-949}
}
Meiotic recombination is induced by the formation of DNA double-strand breaks (DSBs) catalyzed by SPO11, the ortholog of subunit A of TopoVI DNA topoisomerase (TopoVIA). TopoVI activity requires the interaction between A and B subunits. We identified a conserved family of plant and animal proteins [the TOPOVIB-Like (TOPOVIBL) family] that share strong structural similarity to the TopoVIB subunit of TopoVI DNA topoisomerase. We further characterize the meiotic recombination proteins Rec102… CONTINUE READING