The Toll and Imd pathways are the major regulators of the immune response in Drosophila.

@article{Gregorio2002TheTA,
  title={The Toll and Imd pathways are the major regulators of the immune response in Drosophila.},
  author={Ennio De Gregorio and Paul T. Spellman and Phoebe Tzou and Gerald M. Rubin and Bruno Lemaitre},
  journal={The EMBO journal},
  year={2002},
  volume={21 11},
  pages={2568-79}
}
Microarray studies have shown recently that microbial infection leads to extensive changes in the Drosophila gene expression programme. However, little is known about the control of most of the fly immune-responsive genes, except for the antimicrobial peptide (AMP)-encoding genes, which are regulated by the Toll and Imd pathways. Here, we used oligonucleotide microarrays to monitor the effect of mutations affecting the Toll and Imd pathways on the expression programme induced by septic injury… CONTINUE READING
Highly Influential
This paper has highly influenced 35 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 269 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

  • E. De Gregorio, P. T. Spellman, G. M. Rubin, B. Lemaitre
  • Proc. Natl Acad. Sci. USA,
  • 2001
Highly Influential
4 Excerpts

2002a) How Drosophila combats microbial infection: a model to study innate immunity and host±pathogen interactions

  • P. Tzou, E. De Gregorio, B. Lemaitre
  • Curr. Opin. Microbiol.,
  • 2002
Highly Influential
12 Excerpts

Methods for studying infection and immunity in Drosophila

  • P. Tzou, M. Meister, B. Lemaitre
  • Methods Microbiol.,
  • 2002
Highly Influential
12 Excerpts

Similar Papers

Loading similar papers…