The Tissue Plasminogen Activator – Plasminogen Proteolytic Cascade Accelerates Amyloid-( A ) Degradation and Inhibits A-Induced Neurodegeneration

@inproceedings{Melchor2003TheTP,
  title={The Tissue Plasminogen Activator – Plasminogen Proteolytic Cascade Accelerates Amyloid-( A ) Degradation and Inhibits A-Induced Neurodegeneration},
  author={Jerry P. Melchor and Robert J. Pawlak and Sidney Strickland},
  year={2003}
}
Accumulation of the amyloid(A ) peptide depends on both its generation and clearance. To better define clearance pathways, we have evaluated the role of the tissue plasminogen activator (tPA)–plasmin system in A degradation in vivo. In two different mouse models of Alzheimer’s disease, chronically elevated A peptide in the brain correlates with the upregulation of plasminogen activator inhibitor-1 (PAI-1) and inhibition of the tPA–plasmin system. In addition, A injected into the hippocampus of… CONTINUE READING