The Tiresias complex: Huntington's disease as a paradigm of testing for late‐onset disorders
@article{Wexler1992TheTC, title={The Tiresias complex: Huntington's disease as a paradigm of testing for late‐onset disorders}, author={Nancy S Wexler}, journal={The FASEB Journal}, year={1992}, volume={6}, pages={2820 - 2825} }
Huntington's disease represents the first disorder for which positional cloning techniques successfully localized an autosomal gene — in 1983. Events since that time have proved the gene recalcitrant to identification and characterization. Since 1986, presymptomatic and prenatal testing for Huntington's disease has been available internationally, although on a limited basis. Testing for Huntington's disease provides an excellent model for designing service programs for genetic testing for late…
63 Citations
Presymptomatic testing for late‐onset genetic disorders: lessons from Huntington's disease
- MedicineFASEB journal : official publication of the Federation of American Societies for Experimental Biology
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This work has shown that Huntington's disease is a model for other disorders of adult onset for which testing is becoming possible, and the successful resolution of these ethical issues is of great importance.
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