The Tiresias complex: Huntington's disease as a paradigm of testing for late‐onset disorders

@article{Wexler1992TheTC,
  title={The Tiresias complex: Huntington's disease as a paradigm of testing for late‐onset disorders},
  author={Nancy S Wexler},
  journal={The FASEB Journal},
  year={1992},
  volume={6},
  pages={2820 - 2825}
}
  • N. Wexler
  • Published 1 July 1992
  • Medicine
  • The FASEB Journal
Huntington's disease represents the first disorder for which positional cloning techniques successfully localized an autosomal gene — in 1983. Events since that time have proved the gene recalcitrant to identification and characterization. Since 1986, presymptomatic and prenatal testing for Huntington's disease has been available internationally, although on a limited basis. Testing for Huntington's disease provides an excellent model for designing service programs for genetic testing for late… 
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Presymptomatic testing for late‐onset genetic disorders: lessons from Huntington's disease

  • D. BallP. Harper
  • Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1992
This work has shown that Huntington's disease is a model for other disorders of adult onset for which testing is becoming possible, and the successful resolution of these ethical issues is of great importance.

Huntington's disease.

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The prevention of neurogenetic disease.

Advances in gene identification for these diseases will lead in the near future to the means to prevent many of them, and this molecular genotyping will be of indispensible value to families with these diseases when somatic cell gene therapy becomes available.

Ethical Considerations of Genetic Presymptomatic Testing for Huntington's Disease

It is recommended that medical professionals follow strict protocol, provide extensive counseling, and employ vigilance when assessing at-risk individuals for HD presymptomatic test eligibility to ensure psychological well-being.

Predisposition genetic testing for late-onset disorders in adults. A position paper of the National Society of Genetic Counselors.

Identification of cancer susceptibility genes and of genes leading to several neurogenetic disorders, including Alzheimer disease and some forms of ataxia, represents the start of a cascade of genes to be identified that confer susceptibility to adult-onset diseases.

Presymptomatic Testing for Neurogenetic Diseases in Brazil: Assessing Who Seeks and Who Follows through with Testing

General characteristics of Brazilians who sought presymptomatic testing were similar to many European samples studied previously; and individuals at risk for SCA3 may be at greater risk of depression.

Huntington's Disease: Lessons from and for Molecular Neuroscience

Along the winding road to finding the gene, many lessons were learned by clinicians and scientists alike and the next decade of research offers new challenges and rewards for those involved with Huntington's disease.

Social work and genetic testing: Ethical issues encountered in predictive testing for Huntington disease

The social worker's role in the internationally accepted protocol for provision of predictiveTesting for Huntington Disease (HD) is outlined and some of the complex ethical, emotional and practical issues arising from predictive testing for HD and other similar disorders are highlighted.
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References

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Presymptomatic testing for late‐onset genetic disorders: lessons from Huntington's disease

  • D. BallP. Harper
  • Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1992
This work has shown that Huntington's disease is a model for other disorders of adult onset for which testing is becoming possible, and the successful resolution of these ethical issues is of great importance.

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One would like to claim that the Hereditary Disease Foundation showed extraordinary prescience in choosing workshop topics in 1983. But perhaps it was more of the same good fortune that characterized…

EXCLUSION TESTING FOR HUNTINGTON'S DISEASE IN PREGNANCY WITH A CLOSELY LINKED DNA MARKER

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