The Ties that Bind Localization of the Sister-Chromatid Cohesin Complex on Yeast Chromosomes

@article{OrrWeaver1999TheTT,
  title={The Ties that Bind Localization of the Sister-Chromatid Cohesin Complex on Yeast Chromosomes},
  author={Terry L Orr-Weaver},
  journal={Cell},
  year={1999},
  volume={99},
  pages={1-4}
}
Physical attachment between the replicated copies of each chromosome, the sister chromatids, is essential for their proper segregation during mitosis and meiosis. This attachment has been termed sister-chromatid cohesion. A conserved complex of at least four proteins, the cohesin complex, is necessary for cohesion in mitosis and localizes to chromosomes when sister-chromatid cohesion is present (for review see Nasmyth, 1999). Recent papers show that the cohesin complex preferentially associates… CONTINUE READING