The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.

Abstract

T-cell lymphoma invasion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifically activates the Rho-family GTPase Rac1 in response to upstream signals, thereby regulating cellular processes including cell adhesion and migration. Tiam1 contains multiple domains, including an N-terminal pleckstrin homology coiled… (More)
DOI: 10.1074/jbc.M117.799114

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Cite this paper

@article{Xu2017TheTG, title={The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.}, author={Zhen Xu and Lokesh Gakhar and Fletcher E Bain and M Ashley Spies and Ernesto J Fuentes}, journal={The Journal of biological chemistry}, year={2017}, volume={292 43}, pages={17777-17793} }