The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway

@article{Dorsch1997TheTR,
  title={The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway },
  author={Marion Dorsch and Pang-Dian Fan and Nika N. Danial and Paul B. Rothman and Stephen P Goff},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1947 - 1955}
}
Cytokine receptors of the hematopoietic receptor superfamily lack intrinsic tyrosine kinase domains for the intracellular transmission of their signals. Instead all members of this family associate with Jak family nonreceptor tyrosine kinases. Upon ligand stimulation of the receptors, Jaks are activated to phosphorylate target substrates. These include STAT (signal transducers and activators of transcription) proteins, which after phosphorylation translocate to the nucleus and modulate gene… CONTINUE READING
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