The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter

@inproceedings{Gao2017TheTF,
  title={The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter},
  author={Yuan Gao and Rui Feng Hou and Qiaoling Fei and Lei Fang and Yixin Han and Runlan Cai and Cheng Peng and Yun Qi},
  booktitle={Scientific reports},
  year={2017}
}
Mast cells (MCs) are key effector cells of IgE-FcεRI- or MrgprX2-mediated signaling event. Shuang-Huang-Lian (SHL), a herbal formula from Chinese Pharmacopoeia, has been clinically used in type I hypersensitivity. Our previous study demonstrated that SHL exerted a non-negligible effect on MC stabilization. Herein, we sought to elucidate the molecular mechanisms of the prominent anti-allergic ability of SHL. MrgprX2- and IgE-FcεRI-mediated MC activation in vitro and in vivo models were developed… CONTINUE READING
BETA
1
Twitter Mention